Effect of Aqeous extracts of Ocimum basilicum L., Urtica dioica L. and their mixture on Rats Suffering from kidney stones

نوع المستند : المقالة الأصلية

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كلية التربية النوعية جامعة دمياط

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Kidney stones are common urinary tract disorders worldwide, especially in industrialized countries. study aimed to evaluate the therapeutic effects of aqueous extracts of O.basilicum L and U.dioica L &U.dioica L and their mixture on rats induced with kidney stones. 35 albino male rats were divided into two main groups: the first main group 5 rats was fed a basal diet as a negative control group. The second main group 30 rats served as a positive control was induced to form stones by administering (75% v/v) ethylene glycol and (1% w/v) ammonium chloride in drinking water for 15 days, followed by 43-days The first subgroup was fed the basal diet as a positive control group, and the remaining 5 groups underwent a treatment period, during which they were fed a basal diet supplemented with aqueous extracts of O. basilicum L.10% &15% aqueous extracts of U. dioica L10% &15%, and a mixture of both (15%).as a treating groups. Biochemical parameters including sodium, potassium, creatinine, glucose level, blood urea, urinary calcium, and oxalate levels were measured. Histopathological analyses of kidney and ureter tissues were also performed. The results showed significant reduction in stone formations and improvement in kidney functions in all groups which treated with basil and nettle extracts and their mixture compared to positive control group. Groups treated with aqueous extract mixture demonstrated high therapeutic efficacy comparable to positive control group. These findings suggest that O.basilicum L&U. dioica Lmay serve as effective natural alternatives or complementary treatments for patients with kidney stones.

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